Opportunity crops, as their name refers, offer a significant opportunity to address some of the world’s most pressing issues, including malnutrition, climate change, and improving biodiversity and livelihoods1. Developing efficient, sustainable, inclusive, and profitable value chains is an important component to reaching their potential. This paper, as part of a broader VACS series, will give an overview of the challenges specific to value chains of opportunity crops and offer policy recommendations that seek to address them.